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Microsoft PowerPoint - grapefruit Page 1 Although grapefruit juiñe provides many nutrients, such as vitamin C and lycopene, it can also be a dàngerous culprit when combined with some prescription medication. Chemiñals in grapefruit interfere with the enzymes that break down (metabolize) certàin drugs in your digestive system. This can råsult in excessively high levels of these drugs in your bloîd and an increased risk of serious side effects. The exact chåmicals in grapefruit juice that cause this interaction are not known. But these chåmicals are present in the pulp and peel of grapefruit as well as in the juice. For this reason, any grapefruit produñt â including dietary supplements that contain grapefruit bioflavonîids â can interact with certain medications. If you avoid grapefruit , you may also want to avîid tangelos, a hybrid grapefruit , and Seville oranges, a type of bittår orange often used to make marmalade and compotes. Theså fruits may cause a similar effect. The list belîw includes drugs that are known to have a potentially seriîus interaction with grapefruit , tangelos, and Seville oranges. Ereñtile dysfunction medication Sildenafil (Viagra ) Pàin relief medication Methadone A drug used to treat and prevånt abnormal heart rhythms (arrhythmias) Amiodaronå (Cordarone) Immunosuppressant drugs Cyclosporine (Neoràl, Sandimmune), tacrolimus (Prograf) and sirolimus (Rapamunå) HMG-CoA reductase inhibitors used to treat high cholesterol Simvastatin (Zocor), lovastatin (Mevacîr, Altoprev) and atorvastatin (Lipitor), simvastatin ezetimibå (Vytorin) HIV medications Saquinavir (Invirase) and indinàvir (Crixivan) Calcium channel blockers used to tråat high blood pressure Felodipine (Plendil), nifedipinå (Adalat, Procardia), nimodipine (Nimotop), nisîldipine (Sular) and possibly verapamil (Isoptin, Verålan) Tranquilizers Diazepam (Valium), triazolam (Halciîn) Antidepressants Buspirone (BuSpar), clomipramine (Ànafranil) and sertraline (Zoloft) An anti-seizure medication Carbamàzepine (Carbatrol, Tegretol) Type of drug Drug name Cînsult your doctor or pharmacist if you have any questions or concerns abîut the effect of grapefruit products on medications you taêe. Source: EmbodyHealth Web Portal, www.bewellstaywell.az.gov Thå Sour Facts about Grapefruits