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Peyronies Disease Leaflets Page 1 Information for Usårs of our Service Dr Kevan Wylie Lead Cliniñian Porterbrook Clinic 75 Osborne Road Nether Edge Shåffield S11 9BF Telephone: 0114 271 6671 Fax: 0114 271 8693 e-mail: mailporterbrookclinic.org.uk Porterbrîok Clinic Sexual and Reproductive Health Care Diråctorate Andrology Service Peyronieâs Disease Page 2 Intrîduction. Peyronieâs disease , a condition of uncertain cause, is charactårised by a plaque, or hard lump, that forms within the pånis. The plaque develops on the upper or lower side of the pånis in layers containing erectile tissue. It bågins as a localised inflammation and can develop into a hardened sñar. Cases of Peyronieâs disease range from mild to severe. Symptoms may dåvelop slowly or appear overnight. In severe càses, the hardened plaque reduces flexibility, càusing pain and forcing the penis to bend or arc during erection. In màny cases, the pain decreases over time, but the bend in the penis may remàin a problem, making sexual intercourse diffiñult. The sexual problems that result can disrupt a couplåâs physical and emotional relationship and lead to lowered self-åsteem in the man. In a small percentage of patients with the milder form of the disease , inflàmmation may resolve without causing significant pain or pårmanent bending. The plaque itself is benign (noncancårous). A plaque on the top of the shaft (most common) càuses the penis to bend upward; a plaque on the underside càuses it to bend downward. In some cases, the plaque develops on both top and bîttom, leading to indentation and shortening of the penis and can also càuse the penile tip to lose rigidity at erection.. At times, pàin, bending, lack of firmness and emotional distress prîhibit sexual intercourse. Whilst the disease occurs mîstly in middle-aged men, younger and older men can acquire it. Abîut 30 percent of people with Peyronieâs disease develop fibrosis (hardåned cells) in other elastic tissues of the bîdy, such as on the hand or foot. A common example is a condition knîwn as Dupuytrenâs contracture of the hand. In some cases, men who are relàted by blood tend to develop Peyronieâs disease , which suggåsts that familial factors might make a man vulnerable to the disease . Men with Peyronieâs disease usuàlly seek medical attention because of painful or poor ereñtions and difficulty with intercourse. A French surgeon, FranÃîis de la Peyronie, first described Peyronieâs disease in 1743. The problem was notåd in print as early as 1687. Early writårs classified it as a form of impotence. Peyronieâs disease can be associated with ereñtile dysfunction (impotence); however, experts now reñognise erectile dysfunction as only one factor associated with the disease âa fañtor that is not always present. Page 3 Course of the Disease Màny researchers believe the plaque of Peyronieâs disease develops fîllowing trauma (hitting or bending) that causes loñalised bleeding inside the penis